Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
Identifieur interne : 002284 ( Main/Exploration ); précédent : 002283; suivant : 002285Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
Auteurs : Marcel Smid [Pays-Bas] ; F. Germán Rodríguez-González [Pays-Bas] ; Anieta M. Sieuwerts [Pays-Bas] ; Roberto Salgado [Belgique] ; Wendy J. C. Prager-Van Der Smissen [Pays-Bas] ; Michelle Van Der Vlugt-Daane [Pays-Bas] ; Anne Van Galen [Pays-Bas] ; Serena Nik-Zainal [Royaume-Uni] ; Johan Staaf [Suède] ; Arie B. Brinkman [Pays-Bas] ; Marc J. Van De Vijver [Pays-Bas] ; Andrea L. Richardson [États-Unis] ; Aquila Fatima [Pays-Bas] ; Kim Berentsen [Pays-Bas] ; Adam Butler [Royaume-Uni] ; Sancha Martin [Royaume-Uni] ; Helen R. Davies [Royaume-Uni] ; Reno Debets [Pays-Bas] ; Marion E. Meijer-Van Gelder [Pays-Bas] ; Carolien H. M. Van Deurzen [Pays-Bas] ; Gaëtan Macgrogan [France] ; Gert G. G. M. Van Den Eynden [Belgique] ; Colin Purdie [Royaume-Uni] ; Alastair M. Thompson [Royaume-Uni] ; Carlos Caldas [Royaume-Uni] ; Paul N. Span [Pays-Bas] ; Peter T. Simpson [Australie] ; Sunil R. Lakhani [Australie] ; Steven Van Laere [Belgique] ; Christine Desmedt [Belgique] ; Markus Ringnér [Suède] ; Stefania Tommasi [Italie] ; Jorunn Eyford [Islande] ; Annegien Broeks [Pays-Bas] ; Anne Vincent-Salomon [France] ; P. Andrew Futreal [États-Unis] ; Stian Knappskog [Norvège] ; Tari King [États-Unis] ; Gilles Thomas [France] ; Alain Viari [France] ; Anita Langer D [Norvège] ; Anne-Lise B Rresen-Dale [Norvège] ; Ewan Birney [Royaume-Uni] ; Hendrik G. Stunnenberg [Pays-Bas] ; Mike Stratton [Royaume-Uni] ; John A. Foekens [Pays-Bas] ; John W. M. Martens [Pays-Bas]Source :
- Nature Communications [ 2041-1723 ] ; 2016.
Abstract
A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example,
Url:
DOI: 10.1038/ncomms12910
PubMed: 27666519
PubMed Central: 5052682
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000777
- to stream Pmc, to step Curation: 000776
- to stream Pmc, to step Checkpoint: 000A96
- to stream PubMed, to step Corpus: 001858
- to stream PubMed, to step Curation: 001835
- to stream PubMed, to step Checkpoint: 001835
- to stream Ncbi, to step Merge: 003C00
- to stream Ncbi, to step Curation: 003C00
- to stream Ncbi, to step Checkpoint: 003C00
- to stream Main, to step Merge: 002283
- to stream Main, to step Curation: 002284
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration</title><author><name sortKey="Smid, Marcel" sort="Smid, Marcel" uniqKey="Smid M" first="Marcel" last="Smid">Marcel Smid</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Gonzalez, F German" sort="Rodriguez Gonzalez, F German" uniqKey="Rodriguez Gonzalez F" first="F. Germán" last="Rodríguez-González">F. Germán Rodríguez-González</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sieuwerts, Anieta M" sort="Sieuwerts, Anieta M" uniqKey="Sieuwerts A" first="Anieta M." last="Sieuwerts">Anieta M. Sieuwerts</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" first="Roberto" last="Salgado">Roberto Salgado</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles</institution>, Institut Jules Bordet, Bd de Waterloo 121, B-1000 Brussels,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Pathology/TCRU GZA</institution>, 2610 Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prager Van Der Smissen, Wendy J C" sort="Prager Van Der Smissen, Wendy J C" uniqKey="Prager Van Der Smissen W" first="Wendy J. C." last="Prager-Van Der Smissen">Wendy J. C. Prager-Van Der Smissen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vlugt Daane, Michelle Van Der" sort="Vlugt Daane, Michelle Van Der" uniqKey="Vlugt Daane M" first="Michelle Van Der" last="Vlugt-Daane">Michelle Van Der Vlugt-Daane</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Galen, Anne" sort="Van Galen, Anne" uniqKey="Van Galen A" first="Anne" last="Van Galen">Anne Van Galen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nik Zainal, Serena" sort="Nik Zainal, Serena" uniqKey="Nik Zainal S" first="Serena" last="Nik-Zainal">Serena Nik-Zainal</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust</institution>, Cambridge CB2 9NB,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Staaf, Johan" sort="Staaf, Johan" uniqKey="Staaf J" first="Johan" last="Staaf">Johan Staaf</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University</institution>, SE-223 81 Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brinkman, Arie B" sort="Brinkman, Arie B" uniqKey="Brinkman A" first="Arie B." last="Brinkman">Arie B. Brinkman</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van De Vijver, Marc J" sort="Van De Vijver, Marc J" uniqKey="Van De Vijver M" first="Marc J." last="Van De Vijver">Marc J. Van De Vijver</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Pathology, Academic Medical Center</institution>, Meibergdreef 9, 1105 AZ Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L." last="Richardson">Andrea L. Richardson</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Department of Pathology, Brigham and Women's Hospital</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Dana-Farber Cancer Institute</institution>, Boston, Massachusetts 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fatima, Aquila" sort="Fatima, Aquila" uniqKey="Fatima A" first="Aquila" last="Fatima">Aquila Fatima</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Berentsen, Kim" sort="Berentsen, Kim" uniqKey="Berentsen K" first="Kim" last="Berentsen">Kim Berentsen</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Butler, Adam" sort="Butler, Adam" uniqKey="Butler A" first="Adam" last="Butler">Adam Butler</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Davies, Helen R" sort="Davies, Helen R" uniqKey="Davies H" first="Helen R." last="Davies">Helen R. Davies</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Debets, Reno" sort="Debets, Reno" uniqKey="Debets R" first="Reno" last="Debets">Reno Debets</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gelder, Marion E Meijer Van" sort="Gelder, Marion E Meijer Van" uniqKey="Gelder M" first="Marion E. Meijer-Van" last="Gelder">Marion E. Meijer-Van Gelder</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Macgrogan, Gaetan" sort="Macgrogan, Gaetan" uniqKey="Macgrogan G" first="Gaëtan" last="Macgrogan">Gaëtan Macgrogan</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Département de Biopathologie,</institution>Institut Bergonié, CS 61283 33076 Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Eynden, Gert G G M" sort="Van Den Eynden, Gert G G M" uniqKey="Van Den Eynden G" first="Gert G. G. M." last="Van Den Eynden">Gert G. G. M. Van Den Eynden</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Pathology/TCRU GZA</institution>, 2610 Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Molecular Immunology Unit, Jules Bordet Institute</institution>, B-1000 Brussels,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Purdie, Colin" sort="Purdie, Colin" uniqKey="Purdie C" first="Colin" last="Purdie">Colin Purdie</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Pathology, Ninewells Hospital & Medical School</institution>, Dundee DD1 9SY,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Alastair M" sort="Thompson, Alastair M" uniqKey="Thompson A" first="Alastair M." last="Thompson">Alastair M. Thompson</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Pathology, Ninewells Hospital & Medical School</institution>, Dundee DD1 9SY,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Cancer Research UK Cambridge Institute, University of Cambridge</institution>, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Span, Paul N" sort="Span, Paul N" uniqKey="Span P" first="Paul N." last="Span">Paul N. Span</name><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Department of Radiation Oncology, Radboud University Medical Center</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Laboratory Medicine, Radboud University Medical Center</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simpson, Peter T" sort="Simpson, Peter T" uniqKey="Simpson P" first="Peter T." last="Simpson">Peter T. Simpson</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>The University of Queensland: UQ Centre for Clinical Research and School of Medicine</institution>, Brisbane 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>The University of Queensland: UQ Centre for Clinical Research and School of Medicine</institution>, Brisbane 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Pathology Queensland, The Royal Brisbane and Women's Hospital</institution>, Brisbane 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Laere, Steven" sort="Van Laere, Steven" uniqKey="Van Laere S" first="Steven" last="Van Laere">Steven Van Laere</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Center for Oncological Research, University of Antwerp & GZA Hospitals Sint-Augustinus</institution>, 2610 Wilrijk,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Desmedt, Christine" sort="Desmedt, Christine" uniqKey="Desmedt C" first="Christine" last="Desmedt">Christine Desmedt</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles</institution>, Institut Jules Bordet, Bd de Waterloo 121, B-1000 Brussels,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ringner, Markus" sort="Ringner, Markus" uniqKey="Ringner M" first="Markus" last="Ringnér">Markus Ringnér</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University</institution>, SE-223 81 Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tommasi, Stefania" sort="Tommasi, Stefania" uniqKey="Tommasi S" first="Stefania" last="Tommasi">Stefania Tommasi</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>IRCCS Istituto Tumori ‘Giovanni Paolo II'</institution>, 70124 Bari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eyford, Jorunn" sort="Eyford, Jorunn" uniqKey="Eyford J" first="Jorunn" last="Eyford">Jorunn Eyford</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Cancer Research Laboratory, Faculty of Medicine, University of Iceland</institution>, 101 Reykjavik,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="a23"><institution>The Netherlands Cancer Institute</institution>, 1066CX Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Pathology and INSERM U934, Institut Curie</institution>, 26 rue d'Ulm, 75248 Paris Cedex 05,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P. Andrew" last="Futreal">P. Andrew Futreal</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Department of Genomic Medicine, UT MD Anderson Cancer Center</institution>, Houston, TX, 77230,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knappskog, Stian" sort="Knappskog, Stian" uniqKey="Knappskog S" first="Stian" last="Knappskog">Stian Knappskog</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Department of Clinical Science, University of Bergen</institution>, 5020 Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Department of Oncology, Haukeland University Hospital</institution>, 5021 Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="King, Tari" sort="King, Tari" uniqKey="King T" first="Tari" last="King">Tari King</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Memorial Sloan Kettering Cancer Center</institution>, 1275 York Ave, New York, New York 10065,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Gilles" sort="Thomas, Gilles" uniqKey="Thomas G" first="Gilles" last="Thomas">Gilles Thomas</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Synergie Lyon Cancer,Centre Léon Bérard</institution>, 28 rue Laënnec, Cedex 08 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viari, Alain" sort="Viari, Alain" uniqKey="Viari A" first="Alain" last="Viari">Alain Viari</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Synergie Lyon Cancer,Centre Léon Bérard</institution>, 28 rue Laënnec, Cedex 08 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Equipe Erable, INRIA Grenoble-Rhône-Alpes</institution>, 655, Av. de l'Europe, 38330 Montbonnot-Saint Martin,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Langer D, Anita" sort="Langer D, Anita" uniqKey="Langer D A" first="Anita" last="Langer D">Anita Langer D</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital The Norwegian Radiumhospital</institution>, 0310, Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a32"><institution>K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo</institution>, 0310 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital The Norwegian Radiumhospital</institution>, 0310, Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a32"><institution>K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo</institution>, 0310 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Birney, Ewan" sort="Birney, Ewan" uniqKey="Birney E" first="Ewan" last="Birney">Ewan Birney</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus</institution>,Hinxton CB10 1SD, Cambridgeshire,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stunnenberg, Hendrik G" sort="Stunnenberg, Hendrik G" uniqKey="Stunnenberg H" first="Hendrik G." last="Stunnenberg">Hendrik G. Stunnenberg</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stratton, Mike" sort="Stratton, Mike" uniqKey="Stratton M" first="Mike" last="Stratton">Mike Stratton</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foekens, John A" sort="Foekens, John A" uniqKey="Foekens J" first="John A." last="Foekens">John A. Foekens</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27666519</idno><idno type="pmc">5052682</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052682</idno><idno type="RBID">PMC:5052682</idno><idno type="doi">10.1038/ncomms12910</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000777</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000777</idno><idno type="wicri:Area/Pmc/Curation">000776</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000776</idno><idno type="wicri:Area/Pmc/Checkpoint">000A96</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A96</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001858</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001858</idno><idno type="wicri:Area/PubMed/Curation">001835</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001835</idno><idno type="wicri:Area/PubMed/Checkpoint">001835</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001835</idno><idno type="wicri:Area/Ncbi/Merge">003C00</idno><idno type="wicri:Area/Ncbi/Curation">003C00</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C00</idno><idno type="wicri:Area/Main/Merge">002283</idno><idno type="wicri:Area/Main/Curation">002284</idno><idno type="wicri:Area/Main/Exploration">002284</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration</title><author><name sortKey="Smid, Marcel" sort="Smid, Marcel" uniqKey="Smid M" first="Marcel" last="Smid">Marcel Smid</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Gonzalez, F German" sort="Rodriguez Gonzalez, F German" uniqKey="Rodriguez Gonzalez F" first="F. Germán" last="Rodríguez-González">F. Germán Rodríguez-González</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sieuwerts, Anieta M" sort="Sieuwerts, Anieta M" uniqKey="Sieuwerts A" first="Anieta M." last="Sieuwerts">Anieta M. Sieuwerts</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" first="Roberto" last="Salgado">Roberto Salgado</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles</institution>, Institut Jules Bordet, Bd de Waterloo 121, B-1000 Brussels,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Pathology/TCRU GZA</institution>, 2610 Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prager Van Der Smissen, Wendy J C" sort="Prager Van Der Smissen, Wendy J C" uniqKey="Prager Van Der Smissen W" first="Wendy J. C." last="Prager-Van Der Smissen">Wendy J. C. Prager-Van Der Smissen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vlugt Daane, Michelle Van Der" sort="Vlugt Daane, Michelle Van Der" uniqKey="Vlugt Daane M" first="Michelle Van Der" last="Vlugt-Daane">Michelle Van Der Vlugt-Daane</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Galen, Anne" sort="Van Galen, Anne" uniqKey="Van Galen A" first="Anne" last="Van Galen">Anne Van Galen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nik Zainal, Serena" sort="Nik Zainal, Serena" uniqKey="Nik Zainal S" first="Serena" last="Nik-Zainal">Serena Nik-Zainal</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust</institution>, Cambridge CB2 9NB,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Staaf, Johan" sort="Staaf, Johan" uniqKey="Staaf J" first="Johan" last="Staaf">Johan Staaf</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University</institution>, SE-223 81 Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brinkman, Arie B" sort="Brinkman, Arie B" uniqKey="Brinkman A" first="Arie B." last="Brinkman">Arie B. Brinkman</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van De Vijver, Marc J" sort="Van De Vijver, Marc J" uniqKey="Van De Vijver M" first="Marc J." last="Van De Vijver">Marc J. Van De Vijver</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Pathology, Academic Medical Center</institution>, Meibergdreef 9, 1105 AZ Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L." last="Richardson">Andrea L. Richardson</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Department of Pathology, Brigham and Women's Hospital</institution>, Boston, Massachusetts 02115,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Dana-Farber Cancer Institute</institution>, Boston, Massachusetts 02215,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fatima, Aquila" sort="Fatima, Aquila" uniqKey="Fatima A" first="Aquila" last="Fatima">Aquila Fatima</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Berentsen, Kim" sort="Berentsen, Kim" uniqKey="Berentsen K" first="Kim" last="Berentsen">Kim Berentsen</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Butler, Adam" sort="Butler, Adam" uniqKey="Butler A" first="Adam" last="Butler">Adam Butler</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Davies, Helen R" sort="Davies, Helen R" uniqKey="Davies H" first="Helen R." last="Davies">Helen R. Davies</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Debets, Reno" sort="Debets, Reno" uniqKey="Debets R" first="Reno" last="Debets">Reno Debets</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gelder, Marion E Meijer Van" sort="Gelder, Marion E Meijer Van" uniqKey="Gelder M" first="Marion E. Meijer-Van" last="Gelder">Marion E. Meijer-Van Gelder</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Macgrogan, Gaetan" sort="Macgrogan, Gaetan" uniqKey="Macgrogan G" first="Gaëtan" last="Macgrogan">Gaëtan Macgrogan</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Département de Biopathologie,</institution>Institut Bergonié, CS 61283 33076 Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Eynden, Gert G G M" sort="Van Den Eynden, Gert G G M" uniqKey="Van Den Eynden G" first="Gert G. G. M." last="Van Den Eynden">Gert G. G. M. Van Den Eynden</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Pathology/TCRU GZA</institution>, 2610 Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Molecular Immunology Unit, Jules Bordet Institute</institution>, B-1000 Brussels,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Purdie, Colin" sort="Purdie, Colin" uniqKey="Purdie C" first="Colin" last="Purdie">Colin Purdie</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Pathology, Ninewells Hospital & Medical School</institution>, Dundee DD1 9SY,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Alastair M" sort="Thompson, Alastair M" uniqKey="Thompson A" first="Alastair M." last="Thompson">Alastair M. Thompson</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Pathology, Ninewells Hospital & Medical School</institution>, Dundee DD1 9SY,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Cancer Research UK Cambridge Institute, University of Cambridge</institution>, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Span, Paul N" sort="Span, Paul N" uniqKey="Span P" first="Paul N." last="Span">Paul N. Span</name><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Department of Radiation Oncology, Radboud University Medical Center</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Laboratory Medicine, Radboud University Medical Center</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simpson, Peter T" sort="Simpson, Peter T" uniqKey="Simpson P" first="Peter T." last="Simpson">Peter T. Simpson</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>The University of Queensland: UQ Centre for Clinical Research and School of Medicine</institution>, Brisbane 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>The University of Queensland: UQ Centre for Clinical Research and School of Medicine</institution>, Brisbane 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Pathology Queensland, The Royal Brisbane and Women's Hospital</institution>, Brisbane 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Laere, Steven" sort="Van Laere, Steven" uniqKey="Van Laere S" first="Steven" last="Van Laere">Steven Van Laere</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Center for Oncological Research, University of Antwerp & GZA Hospitals Sint-Augustinus</institution>, 2610 Wilrijk,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Desmedt, Christine" sort="Desmedt, Christine" uniqKey="Desmedt C" first="Christine" last="Desmedt">Christine Desmedt</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles</institution>, Institut Jules Bordet, Bd de Waterloo 121, B-1000 Brussels,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ringner, Markus" sort="Ringner, Markus" uniqKey="Ringner M" first="Markus" last="Ringnér">Markus Ringnér</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University</institution>, SE-223 81 Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tommasi, Stefania" sort="Tommasi, Stefania" uniqKey="Tommasi S" first="Stefania" last="Tommasi">Stefania Tommasi</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>IRCCS Istituto Tumori ‘Giovanni Paolo II'</institution>, 70124 Bari,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eyford, Jorunn" sort="Eyford, Jorunn" uniqKey="Eyford J" first="Jorunn" last="Eyford">Jorunn Eyford</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Cancer Research Laboratory, Faculty of Medicine, University of Iceland</institution>, 101 Reykjavik,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="a23"><institution>The Netherlands Cancer Institute</institution>, 1066CX Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Pathology and INSERM U934, Institut Curie</institution>, 26 rue d'Ulm, 75248 Paris Cedex 05,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P. Andrew" last="Futreal">P. Andrew Futreal</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Department of Genomic Medicine, UT MD Anderson Cancer Center</institution>, Houston, TX, 77230,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knappskog, Stian" sort="Knappskog, Stian" uniqKey="Knappskog S" first="Stian" last="Knappskog">Stian Knappskog</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Department of Clinical Science, University of Bergen</institution>, 5020 Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Department of Oncology, Haukeland University Hospital</institution>, 5021 Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="King, Tari" sort="King, Tari" uniqKey="King T" first="Tari" last="King">Tari King</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Memorial Sloan Kettering Cancer Center</institution>, 1275 York Ave, New York, New York 10065,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Gilles" sort="Thomas, Gilles" uniqKey="Thomas G" first="Gilles" last="Thomas">Gilles Thomas</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Synergie Lyon Cancer,Centre Léon Bérard</institution>, 28 rue Laënnec, Cedex 08 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viari, Alain" sort="Viari, Alain" uniqKey="Viari A" first="Alain" last="Viari">Alain Viari</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Synergie Lyon Cancer,Centre Léon Bérard</institution>, 28 rue Laënnec, Cedex 08 Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Equipe Erable, INRIA Grenoble-Rhône-Alpes</institution>, 655, Av. de l'Europe, 38330 Montbonnot-Saint Martin,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Langer D, Anita" sort="Langer D, Anita" uniqKey="Langer D A" first="Anita" last="Langer D">Anita Langer D</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital The Norwegian Radiumhospital</institution>, 0310, Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a32"><institution>K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo</institution>, 0310 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital The Norwegian Radiumhospital</institution>, 0310, Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a32"><institution>K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo</institution>, 0310 Oslo,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Birney, Ewan" sort="Birney, Ewan" uniqKey="Birney E" first="Ewan" last="Birney">Ewan Birney</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus</institution>,Hinxton CB10 1SD, Cambridgeshire,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stunnenberg, Hendrik G" sort="Stunnenberg, Hendrik G" uniqKey="Stunnenberg H" first="Hendrik G." last="Stunnenberg">Hendrik G. Stunnenberg</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen</institution>, 6525GA, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stratton, Mike" sort="Stratton, Mike" uniqKey="Stratton M" first="Mike" last="Stratton">Mike Stratton</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Wellcome Trust Sanger Institute</institution>, Hinxton CB10 1SA, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foekens, John A" sort="Foekens, John A" uniqKey="Foekens J" first="John A." last="Foekens">John A. Foekens</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center</institution>, 3015CN Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example, <italic>TP53, PIK3CA, PTEN, CCND1</italic> and <italic>CDH1</italic>. We find that <italic>CCND3</italic> expression levels do not correlate with amplification, while increased <italic>GATA3</italic> expression in mutant <italic>GATA3</italic> cancers suggests <italic>GATA3</italic> is an oncogene. In luminal cases the total number of substitutions, irrespective of type, associates with cell cycle gene expression and adverse outcome, whereas the number of mutations of signatures 3 and 13 associates with immune-response specific gene expression, increased numbers of tumour-infiltrating lymphocytes and better outcome. Thus, while earlier reports imply that the sheer number of somatic aberrations could trigger an immune-response, our data suggests that substitutions of a particular type are more effective in doing so than others.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Alexandrov, L B" uniqKey="Alexandrov L">L. B. Alexandrov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banerji, S" uniqKey="Banerji S">S. Banerji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curtis, C" uniqKey="Curtis C">C. Curtis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nik Zainal, S" uniqKey="Nik Zainal S">S. Nik-Zainal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paquet, E R" uniqKey="Paquet E">E. R. Paquet</name></author><author><name sortKey="Hallett, M T" uniqKey="Hallett M">M. T. Hallett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pleasance, E D" uniqKey="Pleasance E">E. D. Pleasance</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephens, P J" uniqKey="Stephens P">P. J. Stephens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nik Zainal, S" uniqKey="Nik Zainal S">S. Nik-Zainal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perou, C M" uniqKey="Perou C">C. M. Perou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smid, M" uniqKey="Smid M">M. Smid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorlie, T" uniqKey="Sorlie T">T. Sorlie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langerod, A" uniqKey="Langerod A">A. Langerod</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manie, E" uniqKey="Manie E">E. Manie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Usary, J" uniqKey="Usary J">J. Usary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holm, K" uniqKey="Holm K">K. Holm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, P G" uniqKey="Roy P">P. G. Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berx, G" uniqKey="Berx G">G. Berx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berx, G" uniqKey="Berx G">G. Berx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walerych, D" uniqKey="Walerych D">D. Walerych</name></author><author><name sortKey="Napoli, M" uniqKey="Napoli M">M. Napoli</name></author><author><name sortKey="Collavin, L" uniqKey="Collavin L">L. Collavin</name></author><author><name sortKey="Del Sal, G" uniqKey="Del Sal G">G. Del Sal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leiserson, M D" uniqKey="Leiserson M">M. D. Leiserson</name></author><author><name sortKey="Wu, H T" uniqKey="Wu H">H. T. Wu</name></author><author><name sortKey="Vandin, F" uniqKey="Vandin F">F. Vandin</name></author><author><name sortKey="Raphael, B J" uniqKey="Raphael B">B. J. Raphael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massink, M P" uniqKey="Massink M">M. P. Massink</name></author><author><name sortKey="Kooi, I E" uniqKey="Kooi I">I. E. Kooi</name></author><author><name sortKey="Martens, J W" uniqKey="Martens J">J. W. Martens</name></author><author><name sortKey="Waisfisz, Q" uniqKey="Waisfisz Q">Q. Waisfisz</name></author><author><name sortKey="Meijers Heijboer, H" uniqKey="Meijers Heijboer H">H. Meijers-Heijboer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lundegaard, C" uniqKey="Lundegaard C">C. Lundegaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nielsen, M" uniqKey="Nielsen M">M. Nielsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chowell, D" uniqKey="Chowell D">D. Chowell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J. Sidney</name></author><author><name sortKey="Pinilla, C" uniqKey="Pinilla C">C. Pinilla</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B. Peters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reis Filho, J S" uniqKey="Reis Filho J">J. S. Reis-Filho</name></author><author><name sortKey="Pusztai, L" uniqKey="Pusztai L">L. Pusztai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, J X" uniqKey="Yu J">J. X. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berns, E M" uniqKey="Berns E">E. M. Berns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liao, D J" uniqKey="Liao D">D. J. Liao</name></author><author><name sortKey="Dickson, R B" uniqKey="Dickson R">R. B. Dickson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olivier, M" uniqKey="Olivier M">M. Olivier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haricharan, S" uniqKey="Haricharan S">S. Haricharan</name></author><author><name sortKey="Bainbridge, M N" uniqKey="Bainbridge M">M. N. Bainbridge</name></author><author><name sortKey="Scheet, P" uniqKey="Scheet P">P. Scheet</name></author><author><name sortKey="Brown, P H" uniqKey="Brown P">P. H. Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Verschuer, V M" uniqKey="Van Verschuer V">V. M. van Verschuer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bane, A L" uniqKey="Bane A">A. L. Bane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schumacher, T N" uniqKey="Schumacher T">T. N. Schumacher</name></author><author><name sortKey="Schreiber, R D" uniqKey="Schreiber R">R. D. Schreiber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rizvi, N A" uniqKey="Rizvi N">N. A. Rizvi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snyder, A" uniqKey="Snyder A">A. Snyder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisen, M B" uniqKey="Eisen M">M. B. Eisen</name></author><author><name sortKey="Spellman, P T" uniqKey="Spellman P">P. T. Spellman</name></author><author><name sortKey="Brown, P O" uniqKey="Brown P">P. O. Brown</name></author><author><name sortKey="Botstein, D" uniqKey="Botstein D">D. Botstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goeman, J J" uniqKey="Goeman J">J. J. Goeman</name></author><author><name sortKey="Van De Geer, S A" uniqKey="Van De Geer S">S. A. van de Geer</name></author><author><name sortKey="De Kort, F" uniqKey="De Kort F">F. de Kort</name></author><author><name sortKey="Van Houwelingen, H C" uniqKey="Van Houwelingen H">H. C. van Houwelingen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M. Kanehisa</name></author><author><name sortKey="Goto, S" uniqKey="Goto S">S. Goto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kyte, J" uniqKey="Kyte J">J. Kyte</name></author><author><name sortKey="Doolittle, R F" uniqKey="Doolittle R">R. F. Doolittle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccall, M N" uniqKey="Mccall M">M. N. McCall</name></author><author><name sortKey="Bolstad, B M" uniqKey="Bolstad B">B. M. Bolstad</name></author><author><name sortKey="Irizarry, R A" uniqKey="Irizarry R">R. A. Irizarry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, W E" uniqKey="Johnson W">W. E. Johnson</name></author><author><name sortKey="Li, C" uniqKey="Li C">C. Li</name></author><author><name sortKey="Rabinovic, A" uniqKey="Rabinovic A">A. Rabinovic</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li><li>Islande</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Smid, Marcel" sort="Smid, Marcel" uniqKey="Smid M" first="Marcel" last="Smid">Marcel Smid</name></noRegion><name sortKey="Berentsen, Kim" sort="Berentsen, Kim" uniqKey="Berentsen K" first="Kim" last="Berentsen">Kim Berentsen</name><name sortKey="Brinkman, Arie B" sort="Brinkman, Arie B" uniqKey="Brinkman A" first="Arie B." last="Brinkman">Arie B. Brinkman</name><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><name sortKey="Debets, Reno" sort="Debets, Reno" uniqKey="Debets R" first="Reno" last="Debets">Reno Debets</name><name sortKey="Fatima, Aquila" sort="Fatima, Aquila" uniqKey="Fatima A" first="Aquila" last="Fatima">Aquila Fatima</name><name sortKey="Foekens, John A" sort="Foekens, John A" uniqKey="Foekens J" first="John A." last="Foekens">John A. Foekens</name><name sortKey="Gelder, Marion E Meijer Van" sort="Gelder, Marion E Meijer Van" uniqKey="Gelder M" first="Marion E. Meijer-Van" last="Gelder">Marion E. Meijer-Van Gelder</name><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><name sortKey="Prager Van Der Smissen, Wendy J C" sort="Prager Van Der Smissen, Wendy J C" uniqKey="Prager Van Der Smissen W" first="Wendy J. C." last="Prager-Van Der Smissen">Wendy J. C. Prager-Van Der Smissen</name><name sortKey="Rodriguez Gonzalez, F German" sort="Rodriguez Gonzalez, F German" uniqKey="Rodriguez Gonzalez F" first="F. Germán" last="Rodríguez-González">F. Germán Rodríguez-González</name><name sortKey="Sieuwerts, Anieta M" sort="Sieuwerts, Anieta M" uniqKey="Sieuwerts A" first="Anieta M." last="Sieuwerts">Anieta M. Sieuwerts</name><name sortKey="Span, Paul N" sort="Span, Paul N" uniqKey="Span P" first="Paul N." last="Span">Paul N. Span</name><name sortKey="Span, Paul N" sort="Span, Paul N" uniqKey="Span P" first="Paul N." last="Span">Paul N. Span</name><name sortKey="Stunnenberg, Hendrik G" sort="Stunnenberg, Hendrik G" uniqKey="Stunnenberg H" first="Hendrik G." last="Stunnenberg">Hendrik G. Stunnenberg</name><name sortKey="Van De Vijver, Marc J" sort="Van De Vijver, Marc J" uniqKey="Van De Vijver M" first="Marc J." last="Van De Vijver">Marc J. Van De Vijver</name><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><name sortKey="Van Galen, Anne" sort="Van Galen, Anne" uniqKey="Van Galen A" first="Anne" last="Van Galen">Anne Van Galen</name><name sortKey="Vlugt Daane, Michelle Van Der" sort="Vlugt Daane, Michelle Van Der" uniqKey="Vlugt Daane M" first="Michelle Van Der" last="Vlugt-Daane">Michelle Van Der Vlugt-Daane</name></country><country name="Belgique"><noRegion><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" first="Roberto" last="Salgado">Roberto Salgado</name></noRegion><name sortKey="Desmedt, Christine" sort="Desmedt, Christine" uniqKey="Desmedt C" first="Christine" last="Desmedt">Christine Desmedt</name><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" first="Roberto" last="Salgado">Roberto Salgado</name><name sortKey="Van Den Eynden, Gert G G M" sort="Van Den Eynden, Gert G G M" uniqKey="Van Den Eynden G" first="Gert G. G. M." last="Van Den Eynden">Gert G. G. M. Van Den Eynden</name><name sortKey="Van Den Eynden, Gert G G M" sort="Van Den Eynden, Gert G G M" uniqKey="Van Den Eynden G" first="Gert G. G. M." last="Van Den Eynden">Gert G. G. M. Van Den Eynden</name><name sortKey="Van Laere, Steven" sort="Van Laere, Steven" uniqKey="Van Laere S" first="Steven" last="Van Laere">Steven Van Laere</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Nik Zainal, Serena" sort="Nik Zainal, Serena" uniqKey="Nik Zainal S" first="Serena" last="Nik-Zainal">Serena Nik-Zainal</name></noRegion><name sortKey="Birney, Ewan" sort="Birney, Ewan" uniqKey="Birney E" first="Ewan" last="Birney">Ewan Birney</name><name sortKey="Butler, Adam" sort="Butler, Adam" uniqKey="Butler A" first="Adam" last="Butler">Adam Butler</name><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name><name sortKey="Davies, Helen R" sort="Davies, Helen R" uniqKey="Davies H" first="Helen R." last="Davies">Helen R. Davies</name><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name><name sortKey="Nik Zainal, Serena" sort="Nik Zainal, Serena" uniqKey="Nik Zainal S" first="Serena" last="Nik-Zainal">Serena Nik-Zainal</name><name sortKey="Purdie, Colin" sort="Purdie, Colin" uniqKey="Purdie C" first="Colin" last="Purdie">Colin Purdie</name><name sortKey="Stratton, Mike" sort="Stratton, Mike" uniqKey="Stratton M" first="Mike" last="Stratton">Mike Stratton</name><name sortKey="Thompson, Alastair M" sort="Thompson, Alastair M" uniqKey="Thompson A" first="Alastair M." last="Thompson">Alastair M. Thompson</name></country><country name="Suède"><noRegion><name sortKey="Staaf, Johan" sort="Staaf, Johan" uniqKey="Staaf J" first="Johan" last="Staaf">Johan Staaf</name></noRegion><name sortKey="Ringner, Markus" sort="Ringner, Markus" uniqKey="Ringner M" first="Markus" last="Ringnér">Markus Ringnér</name></country><country name="États-Unis"><noRegion><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L." last="Richardson">Andrea L. Richardson</name></noRegion><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P. Andrew" last="Futreal">P. Andrew Futreal</name><name sortKey="King, Tari" sort="King, Tari" uniqKey="King T" first="Tari" last="King">Tari King</name><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L." last="Richardson">Andrea L. Richardson</name></country><country name="France"><noRegion><name sortKey="Macgrogan, Gaetan" sort="Macgrogan, Gaetan" uniqKey="Macgrogan G" first="Gaëtan" last="Macgrogan">Gaëtan Macgrogan</name></noRegion><name sortKey="Thomas, Gilles" sort="Thomas, Gilles" uniqKey="Thomas G" first="Gilles" last="Thomas">Gilles Thomas</name><name sortKey="Viari, Alain" sort="Viari, Alain" uniqKey="Viari A" first="Alain" last="Viari">Alain Viari</name><name sortKey="Viari, Alain" sort="Viari, Alain" uniqKey="Viari A" first="Alain" last="Viari">Alain Viari</name><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name></country><country name="Australie"><noRegion><name sortKey="Simpson, Peter T" sort="Simpson, Peter T" uniqKey="Simpson P" first="Peter T." last="Simpson">Peter T. Simpson</name></noRegion><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name></country><country name="Italie"><noRegion><name sortKey="Tommasi, Stefania" sort="Tommasi, Stefania" uniqKey="Tommasi S" first="Stefania" last="Tommasi">Stefania Tommasi</name></noRegion></country><country name="Islande"><noRegion><name sortKey="Eyford, Jorunn" sort="Eyford, Jorunn" uniqKey="Eyford J" first="Jorunn" last="Eyford">Jorunn Eyford</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Knappskog, Stian" sort="Knappskog, Stian" uniqKey="Knappskog S" first="Stian" last="Knappskog">Stian Knappskog</name></noRegion><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><name sortKey="Knappskog, Stian" sort="Knappskog, Stian" uniqKey="Knappskog S" first="Stian" last="Knappskog">Stian Knappskog</name><name sortKey="Langer D, Anita" sort="Langer D, Anita" uniqKey="Langer D A" first="Anita" last="Langer D">Anita Langer D</name><name sortKey="Langer D, Anita" sort="Langer D, Anita" uniqKey="Langer D A" first="Anita" last="Langer D">Anita Langer D</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002284 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002284 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5052682
|texte= Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27666519" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |